STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
slc11a2Solute carrier family 11 member 2. (231 aa)    
Predicted Functional Partners:
slc40a1
Solute carrier family 40 member 1; May be involved in iron export and also in transfer of iron between maternal and fetal circulation.
      
 0.899
aco1
Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.
     
 0.839
slc39a14
Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
  
  
 0.824
fech
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
  
  
 0.812
slc30a9
Zinc transporter 9; May act as a zinc transporter involved in intracellular zinc homeostasis. May play a role as nuclear receptor coactivator. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
   
 
 0.805
ireb2
Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family.
  
  
 0.800
atp7b
ATPase copper-transporting beta.
  
 
 0.777
cybrd1
Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). May reduce dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor (By similarity).
      
 0.776
slc25a37
Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
      
 0.770
atp7a
ATPase copper-transporting alpha.
  
 
 0.769
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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