STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rprmbProtein reprimo B; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle; Belongs to the reprimo family. (102 aa)    
Predicted Functional Partners:
rprm3
Reprimo, TP53-dependent G2 arrest mediator homolog 3.
  
 
0.909
rprma
Protein reprimo A; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle; Belongs to the reprimo family.
  
  
0.903
wdr20a
WD repeat domain 20a.
    
 
 0.770
plekhf2
Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
      
 0.697
plekhh2
Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2.
      
 0.697
lins1
Lines homolog 1.
      
 0.670
fam43a
Family with sequence similarity 43 member A.
   
  
 0.650
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
      
 0.649
pak1ip1
P21-activated protein kinase-interacting protein 1-like; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
      
 0.640
tmem59l
Transmembrane protein 59-like.
   
  
 0.584
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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