STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gucy2gGuanylate cyclase. (1127 aa)    
Predicted Functional Partners:
enpp1
Ectonucleotide pyrophosphatase/phosphodiesterase 1.
     
 0.906
nudt2
Nudix (nucleoside diphosphate-linked moiety X)-type motif 2.
     
 0.905
itpa
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.
    
 0.901
mocs1
Molybdenum cofactor synthesis 1.
   
 0.830
pde6gb
Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b.
   
 
 0.795
pde6b
Phosphodiesterase.
   
 0.773
pde5ab
Phosphodiesterase.
   
 0.771
pde11al
Phosphodiesterase.
   
 0.767
pde11a
Phosphodiesterase.
   
 0.766
pde5aa
Phosphodiesterase 5A, cGMP-specific, a.
   
 0.751
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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