node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc45 | cdc6 | ENSDARP00000064200 | ENSDARP00000008736 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.994 |
cdc45 | cdt1 | ENSDARP00000064200 | ENSDARP00000089247 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Chromatin licensing and DNA replication factor 1. | 0.995 |
cdc45 | dtl | ENSDARP00000064200 | ENSDARP00000033992 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | 0.920 |
cdc45 | mcm10 | ENSDARP00000064200 | ENSDARP00000067338 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). | 0.999 |
cdc45 | pcna | ENSDARP00000064200 | ENSDARP00000070780 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.616 |
cdc45 | rbx1 | ENSDARP00000064200 | ENSDARP00000055431 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | Ring-box 1, E3 ubiquitin protein ligase. | 0.672 |
cdc45 | wdhd1 | ENSDARP00000064200 | ENSDARP00000113096 | CDC45 cell division cycle 45 homolog (S. cerevisiae). | WD repeat and HMG-box DNA-binding protein 1. | 0.998 |
cdc6 | cdc45 | ENSDARP00000008736 | ENSDARP00000064200 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.994 |
cdc6 | cdt1 | ENSDARP00000008736 | ENSDARP00000089247 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
cdc6 | cul4a | ENSDARP00000008736 | ENSDARP00000131646 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cullin 4A; Belongs to the cullin family. | 0.618 |
cdc6 | cul4b | ENSDARP00000008736 | ENSDARP00000124267 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cullin 4B; Belongs to the cullin family. | 0.631 |
cdc6 | ddb1 | ENSDARP00000008736 | ENSDARP00000130126 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Damage-specific DNA-binding protein 1. | 0.527 |
cdc6 | dtl | ENSDARP00000008736 | ENSDARP00000033992 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | 0.958 |
cdc6 | mcm10 | ENSDARP00000008736 | ENSDARP00000067338 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). | 0.996 |
cdc6 | pcna | ENSDARP00000008736 | ENSDARP00000070780 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.712 |
cdc6 | wdhd1 | ENSDARP00000008736 | ENSDARP00000113096 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | WD repeat and HMG-box DNA-binding protein 1. | 0.911 |
cdt1 | cdc45 | ENSDARP00000089247 | ENSDARP00000064200 | Chromatin licensing and DNA replication factor 1. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.995 |
cdt1 | cdc6 | ENSDARP00000089247 | ENSDARP00000008736 | Chromatin licensing and DNA replication factor 1. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
cdt1 | cul4a | ENSDARP00000089247 | ENSDARP00000131646 | Chromatin licensing and DNA replication factor 1. | Cullin 4A; Belongs to the cullin family. | 0.883 |
cdt1 | cul4b | ENSDARP00000089247 | ENSDARP00000124267 | Chromatin licensing and DNA replication factor 1. | Cullin 4B; Belongs to the cullin family. | 0.839 |