Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
chrnb1lCholinergic receptor, nicotinic, beta 1 (muscle)-like. (486 aa)    
Predicted Functional Partners:
chrna2a
Cholinergic receptor, nicotinic, alpha 2a (neuronal).
  
 
 
0.955
chrna2b
Cholinergic receptor, nicotinic, alpha 2b (neuronal).
  
 
 
0.955
chrna4b
Neuronal nicotinic acetylcholine receptor alpha 4 subunit.
  
 
 
0.954
lypd6
Ly6/PLAUR domain-containing protein 6; Acts as an important regulator of embryogenesis through its enhancement of Wnt/beta-catenin signaling. Positively regulates Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6 specifically in plasma membrane rafts and its subsequent internalization into signaling-competent vesicles. Essential for the wnt8-mediated patterning of the mesoderm and neuroectoderm during gastrulation.
    
  0.945
chrna1
Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  
 
0.942
Chrna11
Si:ch211-39a7.1.
  
 
0.941
chrna5
Cholinergic receptor, nicotinic, alpha 5.
  
0.940
chrnb3a
Cholinergic receptor, nicotinic, beta polypeptide 3a.
  
0.940
ENSDARP00000144302
Si:ch73-380n15.2.
  
 
0.940
chrnb3b
Cholinergic receptor, nicotinic, beta polypeptide 3b.
  
0.939
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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