Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panx1aPannexin; Structural component of the gap junctions and the hemichannels. (417 aa)    
Predicted Functional Partners:
panx1b
Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.
     
  0.915
p2rx4a
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
      
 0.834
cx43
Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily.
      
 0.825
calhm1
Calcium homeostasis modulator 1.
      
 0.824
entpd1
Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family.
      
 0.794
caspbl
Caspase b,-like; Belongs to the peptidase C14A family.
    
 
 0.786
entpd8
Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family.
      
 0.780
entpd3
Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.
      
 0.775
caspa
Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]
    
 
 0.774
CALHM1
Si:dkeyp-80c12.5.
      
 0.697
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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