Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
kctd6bBTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. (237 aa)    
Predicted Functional Partners:
cul3b
Cullin 3b; Belongs to the cullin family.
    
 0.979
cul3a
Cullin 3a; Belongs to the cullin family.
    
 
 0.967
cita
Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
      
 0.750
spryd3
SPRY domain-containing 3.
      
 0.750
btbd6b
BTB/POZ domain-containing protein 6-B; Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis (By similarity).
    
 0.729
obscnb
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b.
    
 
 0.727
UBE2M
Si:ch1073-205c8.3; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.687
fbxo45
F-box/SPRY domain-containing protein 1; Belongs to the FBXO45/Fsn family.
      
 0.661
ENSDARP00000156326
Uncharacterized protein.
      
 0.661
LOC100333880
Citron rho-interacting serine/threonine kinase b.
      
 0.630
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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