STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
puf60bPoly(U)-binding-splicing factor PUF60-B; DNA- and RNA-binding protein, involved in transcription repression and pre-mRNA splicing. (520 aa)    
Predicted Functional Partners:
puf60a
Poly-U-binding-splicing factor a.
  
 
 
0.909
fubp1
Far upstream element (FUSE)-binding protein 1.
   
 
 0.881
nrbp2a
Nuclear receptor-binding protein 2a.
   
  
 0.862
sf3b3
Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...]
   
 
 0.856
khsrp
KH-type-splicing regulatory protein.
   
 
 0.768
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1.
    
 
 0.749
ypel1
Protein yippee-like; Belongs to the yippee family.
      
 0.743
ttc23
Tetratricopeptide repeat domain 23.
      
 0.742
eftud2
Elongation factor Tu GTP-binding domain-containing 2.
   
  
 0.735
fam172a
Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family.
   
  
 0.714
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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