STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
map4k5Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (878 aa)    
Predicted Functional Partners:
wwc3
WWC family member 3.
      
 0.745
tnfaip8l1
Tumor necrosis factor alpha-induced protein 8-like protein 1.
   
  
 0.731
pdia6
Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family.
    
 
 0.646
PDCL3
Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).
   
  
 0.634
tbkbp1
TBK1-binding protein 1.
      
 0.629
prdx3
Peroxiredoxin 3.
    
 
 0.606
hivep3a
HIVEP zinc finger 3a.
      
 0.601
ube2e2
Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family.
      
 0.564
uba1
Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family.
   
  
 0.560
tnikb
TRAF2 and NCK-interacting kinase b.
 
    
 0.549
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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