Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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co-expression
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map4k5Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (878 aa)    
Predicted Functional Partners:
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
   
  0.794
wwc3
WWC family member 3.
      
 0.738
traf2b
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.737
map4k2
Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.723
tbkbp1
TBK1-binding protein 1.
      
 0.719
tnfaip8l1
Tumor necrosis factor alpha-induced protein 8-like protein 1.
   
  
 0.699
mapk8ip2
Mitogen-activated protein kinase 8-interacting protein 2.
    
 0.656
unm_sa808
Un-named sa808.
   
  0.614
traf2a
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.614
PDCL3
Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity).
   
  
 0.579
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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