Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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nus1Dehydrodolichyl diphosphate synthase complex subunit nus1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...] (274 aa)    
Predicted Functional Partners:
dhdds
Alkyl transferase; Belongs to the UPP synthase family.
   
 0.999
pdss1
Prenyl (Decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family.
  
 
 0.981
pdss2
Prenyl (decaprenyl) diphosphate synthase, subunit 2; Belongs to the FPP/GGPP synthase family.
  
 
 0.980
ggps1
Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.
  
 
 0.975
fdft1
Farnesyl-diphosphate farnesyltransferase 1.
   
 
 0.964
fnta
Farnesyltransferase, CAAX box, alpha.
     
 0.962
fntb
Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
     
 0.959
fdps
Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.955
dolpp1
Dolichyldiphosphatase 1.
  
 
 0.945
srd5a3
Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity).
   
  
 0.910
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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