Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
meis2bMyeloid ecotropic viral integration site 2.1. (393 aa)    
Predicted Functional Partners:
tshz3b
Teashirt zinc finger homeobox 3b.
   
 0.850
tshz3a
Teashirt zinc finger homeobox 3a.
   
 0.803
hoxa9a
Homeobox protein Hox-A9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
    
 
 0.767
fam222a
Family with sequence similarity 222 member A.
    
   0.726
mab21l2
Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family.
   
 
 0.713
dlx3b
Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family.
    
 
 0.691
wwtr1
WW domain-containing transcription regulator 1.
    
 0.691
yap1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...]
    
 0.691
trmt1l
tRNA methyltransferase 1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
      
 0.689
meis3
Myeloid ecotropic viral integration site 3.
  
 
0.678
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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