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suv39h1a protein (Danio rerio) - STRING interaction network
"suv39h1a" - Histone-lysine N-methyltransferase SUV39H1-A in Danio rerio
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
suv39h1aHistone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3 using monomethylated H3 ’Lys- 9’ as substrate. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 ’Lys-9’ trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa)    
Predicted Functional Partners:
sirt1
Sirtuin (silent mating type information regulation 2 homolog) 1 (710 aa)
     
  0.971
h2afvb
H2A histone family, member Vb (149 aa)
     
  0.951
h2afz
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for ch [...] (128 aa)
     
  0.944
h2afx
Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dose [...] (142 aa)
     
  0.939
zgc:114037
Uncharacterized protein; Zgc-171759; Belongs to the histone H2A family (248 aa)
       
  0.935
RRP8
Ribosomal RNA processing 8, methyltransferase, homolog (yeast) (533 aa)
     
  0.927
hist2h2l
Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (126 aa)
       
  0.926
ENSDARG00000070265
annotation not available (132 aa)
       
  0.925
zgc:101846
Histone H2A; Zgc-101846; Belongs to the histone H2A family (128 aa)
       
  0.925
LOC559220
annotation not available (128 aa)
       
  0.925
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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