Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cables2bCdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (494 aa)    
Predicted Functional Partners:
cdk5
Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily.
    
 
 0.658
Dlk1
Uncharacterized protein.
    
   0.555
fibpa
Fibroblast growth factor (acidic) intracellular-binding protein a.
    
 
 0.533
fibpb-2
Acidic fibroblast growth factor intracellular-binding protein B; Mediates with IER2 FGF-signaling in Kupffer's vesicle ciliogenesis and in the establishment of laterality in the embryo. May be involved in mitogenic function of FGF1 (By similarity).
    
 
 0.533
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
   0.480
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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