STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tsc1aTSC complex subunit 1a. (1128 aa)    
Predicted Functional Partners:
tsc2
TSC complex subunit 2.
   
 0.998
tbc1d7
TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
   
 0.987
rhebl1
Ras homolog, mTORC1-binding-like 1.
   
 0.980
rheb
Ras homolog, mTORC1-binding.
  
 0.978
akt1
Non-specific serine/threonine protein kinase.
    
 0.945
akt2l
V-akt murine thymoma viral oncogene homolog 2,-like.
   
 0.941
gsk3ba
Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.
    
 0.939
akt2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
 0.938
akt3b
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.938
akt3a
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.938
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (30%) [HD]