node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aptx | coq4 | ENSDARP00000035368 | ENSDARP00000140019 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | 0.811 |
aptx | lig1 | ENSDARP00000035368 | ENSDARP00000078609 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | DNA ligase. | 0.763 |
aptx | lig3 | ENSDARP00000035368 | ENSDARP00000068915 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | DNA ligase. | 0.834 |
aptx | lig4 | ENSDARP00000035368 | ENSDARP00000080083 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | DNA ligase. | 0.878 |
aptx | ogg1 | ENSDARP00000035368 | ENSDARP00000078516 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | 8-oxoguanine DNA glycosylase. | 0.773 |
aptx | tdp1 | ENSDARP00000035368 | ENSDARP00000124976 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Tyrosyl-DNA phosphodiesterase 1. | 0.936 |
aptx | wrn | ENSDARP00000035368 | ENSDARP00000133164 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | WRN RecQ-like helicase. | 0.836 |
aptx | xrcc1 | ENSDARP00000035368 | ENSDARP00000023168 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | X-ray repair-complementing defective repair in Chinese hamster cells 1. | 0.930 |
aptx | xrcc5 | ENSDARP00000035368 | ENSDARP00000130807 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.777 |
aptx | xrcc6 | ENSDARP00000035368 | ENSDARP00000096636 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | X-ray repair-complementing defective repair in Chinese hamster cells 6. | 0.827 |
coq4 | aptx | ENSDARP00000140019 | ENSDARP00000035368 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | 0.811 |
lig1 | aptx | ENSDARP00000078609 | ENSDARP00000035368 | DNA ligase. | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | 0.763 |
lig1 | lig3 | ENSDARP00000078609 | ENSDARP00000068915 | DNA ligase. | DNA ligase. | 0.563 |
lig1 | lig4 | ENSDARP00000078609 | ENSDARP00000080083 | DNA ligase. | DNA ligase. | 0.672 |
lig1 | ogg1 | ENSDARP00000078609 | ENSDARP00000078516 | DNA ligase. | 8-oxoguanine DNA glycosylase. | 0.781 |
lig1 | tdp1 | ENSDARP00000078609 | ENSDARP00000124976 | DNA ligase. | Tyrosyl-DNA phosphodiesterase 1. | 0.751 |
lig1 | wrn | ENSDARP00000078609 | ENSDARP00000133164 | DNA ligase. | WRN RecQ-like helicase. | 0.848 |
lig1 | xrcc1 | ENSDARP00000078609 | ENSDARP00000023168 | DNA ligase. | X-ray repair-complementing defective repair in Chinese hamster cells 1. | 0.961 |
lig1 | xrcc5 | ENSDARP00000078609 | ENSDARP00000130807 | DNA ligase. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.933 |
lig1 | xrcc6 | ENSDARP00000078609 | ENSDARP00000096636 | DNA ligase. | X-ray repair-complementing defective repair in Chinese hamster cells 6. | 0.942 |