Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cela1.4Chymotrypsin-like elastase family member 1, tandem duplicate 4; Belongs to the peptidase S1 family. (267 aa)    
Predicted Functional Partners:
gsdmea
Gasdermin Ea.
      
 0.719
pjvk
Pejvakin.
      
 0.685
caspb
Caspase b subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa. Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu. [...]
    
 0.604
gsdmeb
Deafness, autosomal dominant 5.
      
 0.595
ltb4r2a
Leukotriene B4 receptor 2a.
    
 0.501
ltb4r2b
Leukotriene B4 receptor 2b.
    
 0.458
cpa1
Carboxypeptidase A1 (pancreatic).
   
 
 0.420
cpa4
Carboxypeptidase A4.
   
 
 0.420
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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