Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rad18RAD18 E3 ubiquitin protein ligase. (426 aa)    
Predicted Functional Partners:
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.997
hltf
Helicase-like transcription factor.
    
 
 0.992
slf1
SMC5-SMC6 complex localization factor 1.
   
 
 0.990
polh
Polymerase (DNA directed), eta.
    
 
 0.989
fancm
FA complementation group M.
   
 
 0.985
shprh
SNF2 histone linker PHD RING helicase.
    
 
 0.982
rev3l
REV3-like, DNA directed polymerase zeta catalytic subunit.
   
 
 0.974
ENSDARP00000153311
Helicase ATP-binding domain-containing protein.
   
 
 0.973
rad51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 
 0.972
rad52
RAD52 homolog, DNA repair protein.
    
 
 0.970
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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