yju2 protein (Danio rerio) - STRING interaction network

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yju2

Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex ; Belongs to the CWC16 family. YJU2 subfamily. (345 aa)

Predicted Functional Partners:

cwc25

0.999

prpf19

0.998

cwc22

0.997

plrg1

0.996

syf2

0.996

gpatch1

0.988

dhx38

0.988

rbm22

0.985

cdc40

0.985

cdc5l

0.985

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cdc40	cdc5l	ENSDARP00000060431	ENSDARP00000064312	Cell division cycle 40 homolog (S. cerevisiae).	CDC5 cell division cycle 5-like (S. pombe).	0.973
cdc40	cwc22	ENSDARP00000060431	ENSDARP00000013971	Cell division cycle 40 homolog (S. cerevisiae).	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly.	0.986
cdc40	cwc25	ENSDARP00000060431	ENSDARP00000091697	Cell division cycle 40 homolog (S. cerevisiae).	CWC25 spliceosome-associated protein homolog.	0.985
cdc40	dhx38	ENSDARP00000060431	ENSDARP00000131918	Cell division cycle 40 homolog (S. cerevisiae).	DEAH (Asp-Glu-Ala-His) box polypeptide 38.	0.992
cdc40	gpatch1	ENSDARP00000060431	ENSDARP00000014631	Cell division cycle 40 homolog (S. cerevisiae).	G patch domain-containing 1.	0.954
cdc40	plrg1	ENSDARP00000060431	ENSDARP00000054234	Cell division cycle 40 homolog (S. cerevisiae).	Pleiotropic regulator 1.	0.938
cdc40	prpf19	ENSDARP00000060431	ENSDARP00000097371	Cell division cycle 40 homolog (S. cerevisiae).	PRP19/PSO4 homolog (S. cerevisiae).	0.980
cdc40	rbm22	ENSDARP00000060431	ENSDARP00000004055	Cell division cycle 40 homolog (S. cerevisiae).	Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis.	0.972
cdc40	syf2	ENSDARP00000060431	ENSDARP00000090723	Cell division cycle 40 homolog (S. cerevisiae).	Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome.	0.993
cdc40	yju2	ENSDARP00000060431	ENSDARP00000035484	Cell division cycle 40 homolog (S. cerevisiae).	Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex ; Belongs to the CWC16 family. YJU2 subfamily.	0.985
cdc5l	cdc40	ENSDARP00000064312	ENSDARP00000060431	CDC5 cell division cycle 5-like (S. pombe).	Cell division cycle 40 homolog (S. cerevisiae).	0.973
cdc5l	cwc22	ENSDARP00000064312	ENSDARP00000013971	CDC5 cell division cycle 5-like (S. pombe).	Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly.	0.970
cdc5l	cwc25	ENSDARP00000064312	ENSDARP00000091697	CDC5 cell division cycle 5-like (S. pombe).	CWC25 spliceosome-associated protein homolog.	0.944
cdc5l	dhx38	ENSDARP00000064312	ENSDARP00000131918	CDC5 cell division cycle 5-like (S. pombe).	DEAH (Asp-Glu-Ala-His) box polypeptide 38.	0.945
cdc5l	gpatch1	ENSDARP00000064312	ENSDARP00000014631	CDC5 cell division cycle 5-like (S. pombe).	G patch domain-containing 1.	0.862
cdc5l	plrg1	ENSDARP00000064312	ENSDARP00000054234	CDC5 cell division cycle 5-like (S. pombe).	Pleiotropic regulator 1.	0.999
cdc5l	prpf19	ENSDARP00000064312	ENSDARP00000097371	CDC5 cell division cycle 5-like (S. pombe).	PRP19/PSO4 homolog (S. cerevisiae).	0.999
cdc5l	rbm22	ENSDARP00000064312	ENSDARP00000004055	CDC5 cell division cycle 5-like (S. pombe).	Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis.	0.994
cdc5l	syf2	ENSDARP00000064312	ENSDARP00000090723	CDC5 cell division cycle 5-like (S. pombe).	Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome.	0.997
cdc5l	yju2	ENSDARP00000064312	ENSDARP00000035484	CDC5 cell division cycle 5-like (S. pombe).	Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex ; Belongs to the CWC16 family. YJU2 subfamily.	0.985

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