STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yju2Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex ; Belongs to the CWC16 family. YJU2 subfamily. (345 aa)    
Predicted Functional Partners:
plrg1
Pleiotropic regulator 1.
   
 
 0.999
cdc5l
CDC5 cell division cycle 5-like (S. pombe).
   
 
 0.998
cwc25
CWC25 spliceosome-associated protein homolog.
   
 
 0.997
xab2
Similar to Xab2 protein.
   
 
 0.996
bud31
Protein BUD31 homolog; Involved in pre-mRNA splicing process.
   
 
 0.996
dhx38
DEAH (Asp-Glu-Ala-His) box polypeptide 38.
   
 
 0.996
cwc22
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly.
   
 0.995
prpf19
PRP19/PSO4 homolog (S. cerevisiae).
    
 0.995
cdc40
Cell division cycle 40 homolog (S. cerevisiae).
    
 
 0.994
snrnp200
Small nuclear ribonucleoprotein 200 (U5).
    
 
 0.994
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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