node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RANBP2 | ftr52p | ENSDARP00000153036 | ENSDARP00000126374 | Si:ch1073-55a19.2. | FinTRIM family, member 52, pseudogene. | 0.483 |
RANBP2 | rnf4 | ENSDARP00000153036 | ENSDARP00000138497 | Si:ch1073-55a19.2. | Ring finger protein 4. | 0.445 |
RANBP2 | sae1 | ENSDARP00000153036 | ENSDARP00000016138 | Si:ch1073-55a19.2. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.740 |
RANBP2 | sumo3a | ENSDARP00000153036 | ENSDARP00000035513 | Si:ch1073-55a19.2. | Small ubiquitin-related modifier 3-like; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity). | 0.989 |
RANBP2 | uba2 | ENSDARP00000153036 | ENSDARP00000139796 | Si:ch1073-55a19.2. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.791 |
RANBP2 | ube2ia | ENSDARP00000153036 | ENSDARP00000052745 | Si:ch1073-55a19.2. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.997 |
RANBP2 | ube2ib | ENSDARP00000153036 | ENSDARP00000011487 | Si:ch1073-55a19.2. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.996 |
ftr52p | RANBP2 | ENSDARP00000126374 | ENSDARP00000153036 | FinTRIM family, member 52, pseudogene. | Si:ch1073-55a19.2. | 0.483 |
ftr52p | sae1 | ENSDARP00000126374 | ENSDARP00000016138 | FinTRIM family, member 52, pseudogene. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.610 |
ftr52p | sumo3a | ENSDARP00000126374 | ENSDARP00000035513 | FinTRIM family, member 52, pseudogene. | Small ubiquitin-related modifier 3-like; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity). | 0.876 |
ftr52p | uba2 | ENSDARP00000126374 | ENSDARP00000139796 | FinTRIM family, member 52, pseudogene. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.407 |
ftr52p | ube2ia | ENSDARP00000126374 | ENSDARP00000052745 | FinTRIM family, member 52, pseudogene. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.818 |
ftr52p | ube2ib | ENSDARP00000126374 | ENSDARP00000011487 | FinTRIM family, member 52, pseudogene. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.818 |
nedd8 | pcna | ENSDARP00000021095 | ENSDARP00000070780 | NEDD8 ubiquitin-like modifier. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.428 |
nedd8 | rnf4 | ENSDARP00000021095 | ENSDARP00000138497 | NEDD8 ubiquitin-like modifier. | Ring finger protein 4. | 0.437 |
nedd8 | sae1 | ENSDARP00000021095 | ENSDARP00000016138 | NEDD8 ubiquitin-like modifier. | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.612 |
nedd8 | sumo3a | ENSDARP00000021095 | ENSDARP00000035513 | NEDD8 ubiquitin-like modifier. | Small ubiquitin-related modifier 3-like; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity). | 0.795 |
nedd8 | uba2 | ENSDARP00000021095 | ENSDARP00000139796 | NEDD8 ubiquitin-like modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity). Belongs to the ubiquitin-activating E1 family. | 0.749 |
nedd8 | ube2ia | ENSDARP00000021095 | ENSDARP00000052745 | NEDD8 ubiquitin-like modifier. | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.517 |
nedd8 | ube2ib | ENSDARP00000021095 | ENSDARP00000011487 | NEDD8 ubiquitin-like modifier. | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. | 0.568 |