Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
asic4aAcid-sensing ion channel 4-A; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. (539 aa)    
Predicted Functional Partners:
rhbg
Ammonium transporter Rh type B; Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
      
 0.543
nedd4l
NEDD4-like E3 ubiquitin protein ligase.
    
 0.421
nedd4a
E3 ubiquitin-protein ligase.
    
 0.421
pick1
Protein-interacting with prkca 1.
   
 
 0.414
hecw1b
HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1b.
    
 0.407
hecw2b
HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 2b.
    
 0.407
Hecw2b
Uncharacterized protein.
    
 0.407
hecw2a
HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 2a.
    
 0.407
LOC103909734
Si:ch211-188f17.1.
    
 0.407
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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