STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
llgl2LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa)    
Predicted Functional Partners:
prkci
Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.
   
 0.992
prkcz
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    
 0.990
scrib
Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation.
    
 0.950
dlg1l
Discs large homolog 1-like protein; May play a role in synapse assembly and function.
   
 0.943
llgl1
LLGL scribble cell polarity complex component 1.
  
  
0.905
pard6gb
Par-6 partitioning defective 6-like protein gamma.
    
 
 0.864
pard6b
Par-6 partitioning defective 6 homolog beta (C. elegans).
    
 
 0.829
pard6a
Par-6 family cell polarity regulator alpha.
    
 
 0.796
pard6ga
Par-6 family cell polarity regulator gamma a.
    
 
 0.796
prkrip1
PRKR-interacting protein 1 homolog; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).
      
 0.693
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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