mapk14b protein (Danio rerio) - STRING interaction network

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mapk14b

Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)

Predicted Functional Partners:

map2k6

0.979

tp53

0.977

atf2

0.974

mapkapk3

0.970

jun

0.966

mapkapk2a

0.950

mapkapk5

0.948

cdc25b

0.944

mapk1

0.944

rps6ka5

0.942

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
atf2	jun	ENSDARP00000145716	ENSDARP00000063911	Activating transcription factor 2.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.975
atf2	mapk1	ENSDARP00000145716	ENSDARP00000038550	Activating transcription factor 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.855
atf2	mapk14b	ENSDARP00000145716	ENSDARP00000035686	Activating transcription factor 2.	Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...]	0.974
atf2	rps6ka5	ENSDARP00000145716	ENSDARP00000079873	Activating transcription factor 2.	Ribosomal protein S6 kinase.	0.962
cdc25b	mapk1	ENSDARP00000003494	ENSDARP00000038550	Cell division cycle 25B.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.536
cdc25b	mapk14b	ENSDARP00000003494	ENSDARP00000035686	Cell division cycle 25B.	Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...]	0.944
cdc25b	tp53	ENSDARP00000003494	ENSDARP00000116736	Cell division cycle 25B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.622
jun	atf2	ENSDARP00000063911	ENSDARP00000145716	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Activating transcription factor 2.	0.975
jun	map2k6	ENSDARP00000063911	ENSDARP00000143278	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	0.619
jun	mapk1	ENSDARP00000063911	ENSDARP00000038550	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.970
jun	mapk14b	ENSDARP00000063911	ENSDARP00000035686	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...]	0.966
jun	tp53	ENSDARP00000063911	ENSDARP00000116736	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.910
map2k6	jun	ENSDARP00000143278	ENSDARP00000063911	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.619
map2k6	mapk1	ENSDARP00000143278	ENSDARP00000038550	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.978
map2k6	mapk14b	ENSDARP00000143278	ENSDARP00000035686	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...]	0.979
map2k6	mapkapk2a	ENSDARP00000143278	ENSDARP00000020470	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	Mitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.944
map2k6	mapkapk3	ENSDARP00000143278	ENSDARP00000157636	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	MAPK-activated protein kinase 3; Belongs to the protein kinase superfamily.	0.884
map2k6	mapkapk5	ENSDARP00000143278	ENSDARP00000113922	Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...]	Mitogen-activated protein kinase-activated protein kinase 5.	0.747
mapk1	atf2	ENSDARP00000038550	ENSDARP00000145716	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Activating transcription factor 2.	0.855
mapk1	cdc25b	ENSDARP00000038550	ENSDARP00000003494	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Cell division cycle 25B.	0.536

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