STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clic4Chloride intracellular channel 4. (252 aa)    
Predicted Functional Partners:
srsf6b
Serine and arginine-rich-splicing factor 6b.
   
 
 0.575
vat1
Synaptic vesicle membrane protein VAT-1 homolog.
   
  
 0.564
tmc2a
Transmembrane channel-like protein 2-A; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells.
      
 0.533
kcnh8
Potassium voltage-gated channel, subfamily H (eag-related), member 8.
      
 0.502
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
   
  
 0.495
rmdn3
Regulator of microtubule dynamics 3.
    
 
 0.482
arhgef1b
Rho guanine nucleotide exchange factor (GEF) 1b.
      
 0.482
tmc5
Transmembrane channel-like protein.
      
 0.480
slc26a5
Solute carrier family 26, member 5.
      
 0.472
rab32b
RAB32b, member RAS oncogene family.
      
 0.472
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.