Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
clic4Chloride intracellular channel 4. (252 aa)    
Predicted Functional Partners:
gsr
Glutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
 
 0.653
tmc2a
Transmembrane channel-like protein 2-A; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells.
      
 0.583
srsf6b
Serine and arginine-rich-splicing factor 6b.
   
 
 0.580
clic2
Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.
   
 
 0.560
prdx6
Peroxiredoxin 6.
   
 
 0.555
gss
Glutathione synthetase.
     
 0.551
chac2
Putative glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
     
 0.541
chac1
Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Not [...]
     
 0.539
txndc12
Thioredoxin domain-containing 12 (endoplasmic reticulum).
   
  0.521
mgst2
Microsomal glutathione S-transferase 2.
     
  0.514
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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