Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (637 aa)    
Predicted Functional Partners:
appb
Amyloid beta (A4) precursor protein b.
    
 
 0.837
appa
Amyloid beta (A4) precursor protein a.
    
 
 0.837
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
    
 
 0.826
aplp2
Amyloid beta (A4) precursor-like protein 2.
   
 
 0.738
casp6a
Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.
      
 0.674
casp6b.1
Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
      
 0.671
slc15a4
Solute carrier family 15 member 4.
      
 0.665
aplp1
Amyloid beta (A4) precursor-like protein 1.
    
 
 0.661
dr1
Down-regulator of transcription 1.
      
 0.596
tnfrsf19
Tumor necrosis factor receptor superfamily, member 19.
      
 0.580
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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