node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
armc8 | gid8a | ENSDARP00000115627 | ENSDARP00000035630 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | 0.970 |
armc8 | gid8b | ENSDARP00000115627 | ENSDARP00000054737 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | 0.970 |
armc8 | maea | ENSDARP00000115627 | ENSDARP00000070240 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] | 0.900 |
armc8 | ranbp10 | ENSDARP00000115627 | ENSDARP00000123657 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. | 0.937 |
armc8 | ranbp9 | ENSDARP00000115627 | ENSDARP00000081043 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | 0.937 |
armc8 | rmnd5b | ENSDARP00000115627 | ENSDARP00000105253 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | 0.932 |
armc8 | wdr26b | ENSDARP00000115627 | ENSDARP00000036145 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...] | 0.954 |
gid8a | armc8 | ENSDARP00000035630 | ENSDARP00000115627 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | 0.970 |
gid8a | maea | ENSDARP00000035630 | ENSDARP00000070240 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] | 0.723 |
gid8a | ranbp10 | ENSDARP00000035630 | ENSDARP00000123657 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. | 0.847 |
gid8a | ranbp9 | ENSDARP00000035630 | ENSDARP00000081043 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | 0.847 |
gid8a | rmnd5b | ENSDARP00000035630 | ENSDARP00000105253 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | 0.926 |
gid8a | wdr26b | ENSDARP00000035630 | ENSDARP00000036145 | Glucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...] | 0.879 |
gid8b | armc8 | ENSDARP00000054737 | ENSDARP00000115627 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | 0.970 |
gid8b | maea | ENSDARP00000054737 | ENSDARP00000070240 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] | 0.712 |
gid8b | ranbp10 | ENSDARP00000054737 | ENSDARP00000123657 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. | 0.847 |
gid8b | ranbp9 | ENSDARP00000054737 | ENSDARP00000081043 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. | 0.847 |
gid8b | rmnd5b | ENSDARP00000054737 | ENSDARP00000105253 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | 0.926 |
gid8b | wdr26b | ENSDARP00000054737 | ENSDARP00000036145 | Glucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...] | 0.880 |
gsc | wdr26b | ENSDARP00000076522 | ENSDARP00000036145 | Homeobox protein goosecoid. | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...] | 0.922 |