Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ptbp2bPolypyrimidine tract-binding protein 2b. (538 aa)    
Predicted Functional Partners:
nova1
NOVA alternative-splicing regulator 1.
    
 
 0.789
srrm4
Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity).
      
 0.777
raver2
Ribonucleoprotein, PTB-binding 2.
   
 
 0.738
elavl1a
ELAV-like protein; Belongs to the RRM elav family.
   
 
 0.716
ctnnbl1
Catenin, beta-like 1.
   
  
 0.703
raver1
Ribonucleoprotein, PTB-binding 1.
   
 
 0.689
nova2
NOVA alternative-splicing regulator 2.
   
 
 0.683
rbfox1
RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity).
    
 
 0.657
rbfox2
RNA-binding fox-1 homolog 2.
    
 
 0.633
celf1
CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family.
   
 
 0.621
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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