Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tmem178bTransmembrane protein 178B. (294 aa)    
Predicted Functional Partners:
ppp1r9a
Protein phosphatase 1, regulatory subunit 9A.
      
 0.687
clstn2
Calsyntenin 2.
   
  
 0.665
caprin2
Caprin-2; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
      
 0.662
mex3b
Mex-3 RNA-binding family member B.
      
 0.614
sncaip
Synuclein, alpha-interacting protein.
      
 0.614
bnip3lb
BCL2-interacting protein 3-like b.
      
 0.602
phactr1
Phosphatase and actin regulator.
      
 0.562
ank3b
Ankyrin 3b.
      
 0.552
ank3b-2
Zgc:171763 protein.
      
 0.552
lrp1ba
Low density lipoprotein receptor-related protein 1Ba.
   
  
 0.512
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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