node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ecsit | irak1 | ENSDARP00000124710 | ENSDARP00000118154 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Interleukin-1 receptor-associated kinase 1. | 0.422 |
ecsit | irak4 | ENSDARP00000124710 | ENSDARP00000135636 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Interleukin-1 receptor-associated kinase 4. | 0.630 |
ecsit | myd88 | ENSDARP00000124710 | ENSDARP00000020711 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.451 |
ecsit | tab2 | ENSDARP00000124710 | ENSDARP00000019647 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. | 0.458 |
ecsit | tab3 | ENSDARP00000124710 | ENSDARP00000083707 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like. | 0.459 |
ecsit | traf6 | ENSDARP00000124710 | ENSDARP00000036715 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. | 0.996 |
irak1 | ecsit | ENSDARP00000118154 | ENSDARP00000124710 | Interleukin-1 receptor-associated kinase 1. | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | 0.422 |
irak1 | irak4 | ENSDARP00000118154 | ENSDARP00000135636 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.998 |
irak1 | map3k7 | ENSDARP00000118154 | ENSDARP00000006286 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7. | 0.959 |
irak1 | myd88 | ENSDARP00000118154 | ENSDARP00000020711 | Interleukin-1 receptor-associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.999 |
irak1 | sqstm1 | ENSDARP00000118154 | ENSDARP00000117113 | Interleukin-1 receptor-associated kinase 1. | Sequestosome 1. | 0.843 |
irak1 | tab2 | ENSDARP00000118154 | ENSDARP00000019647 | Interleukin-1 receptor-associated kinase 1. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. | 0.984 |
irak1 | tab3 | ENSDARP00000118154 | ENSDARP00000083707 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like. | 0.935 |
irak1 | tirap | ENSDARP00000118154 | ENSDARP00000103037 | Interleukin-1 receptor-associated kinase 1. | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. | 0.976 |
irak1 | traf6 | ENSDARP00000118154 | ENSDARP00000036715 | Interleukin-1 receptor-associated kinase 1. | TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. | 0.999 |
irak1 | ube2na | ENSDARP00000118154 | ENSDARP00000003705 | Interleukin-1 receptor-associated kinase 1. | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. | 0.704 |
irak4 | ecsit | ENSDARP00000135636 | ENSDARP00000124710 | Interleukin-1 receptor-associated kinase 4. | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | 0.630 |
irak4 | irak1 | ENSDARP00000135636 | ENSDARP00000118154 | Interleukin-1 receptor-associated kinase 4. | Interleukin-1 receptor-associated kinase 1. | 0.998 |
irak4 | map3k7 | ENSDARP00000135636 | ENSDARP00000006286 | Interleukin-1 receptor-associated kinase 4. | Mitogen-activated protein kinase kinase kinase 7. | 0.929 |
irak4 | myd88 | ENSDARP00000135636 | ENSDARP00000020711 | Interleukin-1 receptor-associated kinase 4. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.999 |