| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| chuk | irak1 | ENSDARP00000013115 | ENSDARP00000118154 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Interleukin-1 receptor-associated kinase 1. | 0.985 |
| chuk | irak4 | ENSDARP00000013115 | ENSDARP00000135636 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Interleukin-1 receptor-associated kinase 4. | 0.963 |
| chuk | map3k7 | ENSDARP00000013115 | ENSDARP00000006286 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Mitogen-activated protein kinase kinase kinase 7. | 0.978 |
| chuk | myd88 | ENSDARP00000013115 | ENSDARP00000020711 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.875 |
| chuk | sqstm1 | ENSDARP00000013115 | ENSDARP00000117113 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Sequestosome 1. | 0.489 |
| chuk | tab1 | ENSDARP00000013115 | ENSDARP00000053182 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.981 |
| chuk | tab2 | ENSDARP00000013115 | ENSDARP00000019647 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. | 0.993 |
| chuk | tab3 | ENSDARP00000013115 | ENSDARP00000083707 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like. | 0.990 |
| chuk | tirap | ENSDARP00000013115 | ENSDARP00000103037 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. | 0.597 |
| chuk | traf6 | ENSDARP00000013115 | ENSDARP00000036715 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. | 0.998 |
| irak1 | chuk | ENSDARP00000118154 | ENSDARP00000013115 | Interleukin-1 receptor-associated kinase 1. | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | 0.985 |
| irak1 | irak4 | ENSDARP00000118154 | ENSDARP00000135636 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.997 |
| irak1 | map3k7 | ENSDARP00000118154 | ENSDARP00000006286 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7. | 0.995 |
| irak1 | myd88 | ENSDARP00000118154 | ENSDARP00000020711 | Interleukin-1 receptor-associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.999 |
| irak1 | sqstm1 | ENSDARP00000118154 | ENSDARP00000117113 | Interleukin-1 receptor-associated kinase 1. | Sequestosome 1. | 0.928 |
| irak1 | tab1 | ENSDARP00000118154 | ENSDARP00000053182 | Interleukin-1 receptor-associated kinase 1. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.973 |
| irak1 | tab2 | ENSDARP00000118154 | ENSDARP00000019647 | Interleukin-1 receptor-associated kinase 1. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. | 0.995 |
| irak1 | tab3 | ENSDARP00000118154 | ENSDARP00000083707 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like. | 0.994 |
| irak1 | tirap | ENSDARP00000118154 | ENSDARP00000103037 | Interleukin-1 receptor-associated kinase 1. | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. | 0.994 |
| irak1 | traf6 | ENSDARP00000118154 | ENSDARP00000036715 | Interleukin-1 receptor-associated kinase 1. | TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. | 0.999 |
