STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cacul1CDK2-associated cullin domain 1; Belongs to the cullin family. (225 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 
 0.814
JMJD8
Jumonji domain containing 8.
      
 0.806
ptpn13
Protein tyrosine phosphatase non-receptor type 13.
      
 0.805
cdk14
Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily.
    
 
 0.798
mysm1
Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
   
 
 0.770
tnk1
Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.
      
 0.719
ubxn7
UBX domain protein 7.
   
 
 0.702
cdc5l
CDC5 cell division cycle 5-like (S. pombe).
      
 0.670
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 
 0.663
cand2
Cullin-associated and neddylation-dissociated 2 (putative).
   
 
 0.658
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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