Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cacul1CDK2-associated cullin domain 1; Belongs to the cullin family. (225 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 0.927
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.870
ubxn7
UBX domain protein 7.
   
 
 0.819
bag5
BCL2-associated athanogene 5.
    
 
 0.819
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 
 0.775
nedd8
NEDD8 ubiquitin-like modifier.
    
 
 0.770
nedd8l
NEDD8 ubiquitin-like modifier, like.
    
 
 0.770
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 0.764
JMJD8
Jumonji domain containing 8.
      
 0.755
cdk14
Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily.
    
 0.752
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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