Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hcn3Hyperpolarization-activated cyclic nucleotide-gated potassium channel 3. (639 aa)    
Predicted Functional Partners:
hcn4l
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4l.
  
  
 
0.901
hcn2b
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 2b.
  
  
 
0.901
hcn4
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
  
  
 
0.901
LOC100334297
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 1.
  
  
 
0.901
kctd3
Potassium channel tetramerization domain-containing 3.
    
 
 0.887
scn1laa
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    
 0.692
nkain1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Belongs to the NKAIN family.
   
  
 0.584
SLC25A29
Solute carrier family 25 member 29; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.565
slc25a29
Solute carrier family 25 member 29; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.564
kctd14
Potassium channel tetramerization domain-containing 14.
      
 0.560
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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