STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)    
Predicted Functional Partners:
stat1a
Signal transducer and activator of transcription.
   
 0.996
stat2
Signal transducer and activator of transcription.
   
 0.990
socs3a
Suppressor of cytokine-signaling 3a.
   
 0.986
stat1b
Signal transducer and activator of transcription.
   
 0.984
stat3
Signal transducer and activator of transcription.
   
 0.980
socs3b
Suppressor of cytokine-signaling 3b.
   
 0.978
il10rb
Interleukin 10 receptor, beta.
   
 0.963
crfb4
Cytokine receptor family member b4.
   
 0.963
il6st
Interleukin 6 signal transducer.
   
 0.957
ifngr1l
Interferon gamma receptor 1-like.
     
 0.952
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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