STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccnd3Cyclin D3; Belongs to the cyclin family. (277 aa)    
Predicted Functional Partners:
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.994
cdkn1a
Cyclin-dependent kinase inhibitor 1A.
   
 0.962
cdk21
Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily.
   
 0.956
rbl2
Retinoblastoma-like 2 (p130).
    
 0.955
rb1
Retinoblastoma 1.
    
 0.951
rbl1
Retinoblastoma-like 1 (p107).
    
 0.951
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.943
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.943
cdkn2c
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).
    
 0.940
cdkn2d
Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4).
    
 0.939
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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