Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
chrna6Cholinergic receptor, nicotinic, alpha 6. (512 aa)    
Predicted Functional Partners:
chrna4b
Neuronal nicotinic acetylcholine receptor alpha 4 subunit.
  
0.961
chrna2b
Cholinergic receptor, nicotinic, alpha 2b (neuronal).
  
 
0.956
chrna2a
Cholinergic receptor, nicotinic, alpha 2a (neuronal).
  
 
0.954
lypd6
Ly6/PLAUR domain-containing protein 6; Acts as an important regulator of embryogenesis through its enhancement of Wnt/beta-catenin signaling. Positively regulates Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6 specifically in plasma membrane rafts and its subsequent internalization into signaling-competent vesicles. Essential for the wnt8-mediated patterning of the mesoderm and neuroectoderm during gastrulation.
    
  0.945
chrnb3b
Cholinergic receptor, nicotinic, beta polypeptide 3b.
  
0.943
chrnb3a
Cholinergic receptor, nicotinic, beta polypeptide 3a.
  
0.942
chrna7
Cholinergic receptor, nicotinic, alpha 7 (neuronal).
   
0.942
chrna5
Cholinergic receptor, nicotinic, alpha 5.
  
0.940
Chrna11
Si:ch211-39a7.1.
  
 
0.940
ENSDARP00000144302
Si:ch73-380n15.2.
  
 
0.940
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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