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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)    
Predicted Functional Partners:
tbk1
TANK-binding kinase 1.
   
 0.998
tank
TRAF family member-associated NFKB activator.
   
 0.997
mavs
Mitochondrial antiviral-signaling protein.
    
 0.995
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
   
 0.988
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 0.975
ticam1
Toll-like receptor adaptor molecule 1.
   
 0.960
map3k14a
Mitogen-activated protein kinase kinase kinase 14a.
    
 0.956
ripk2
Receptor-interacting serine-threonine kinase 2.
   
 0.955
otud5a
OTU domain-containing protein 5-A; Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).
   
 0.952
irf3
Interferon regulatory factor 3.
   
 0.948
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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