Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)    
Predicted Functional Partners:
tank
TRAF family member-associated NFKB activator.
   
 0.999
tbk1
TANK-binding kinase 1.
   
 0.998
map3k14a
Mitogen-activated protein kinase kinase kinase 14a.
    
 0.997
mavs
Mitochondrial antiviral-signaling protein.
    
 0.995
traf6
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.
    
0.994
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 0.994
birc2
Baculoviral IAP repeat-containing 2.
   
 0.993
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
   
 0.990
cd40
CD40 molecule, TNF receptor superfamily member 5.
   
 0.987
ticam1
Toll-like receptor adaptor molecule 1.
    
 0.986
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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