STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
craddCASP2 and RIPK1 domain-containing adaptor with death domain. (200 aa)    
Predicted Functional Partners:
pidd1
P53-induced death domain protein 1.
     
  0.900
prtgb
Protogenin B; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family.
      
 0.669
sik1
Salt-inducible kinase 1.
   
  
 0.570
hs6st2
Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis.
      
 0.550
socs2
Suppressor of cytokine signaling 2.
 
    
 0.549
bcl10
BCL10 immune-signaling adaptor.
     
  0.540
casp2
Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 
 
0.503
sdhdb
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family.
   
  
 0.486
cdkn2c
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).
      
 0.480
slc9a1b
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      
 0.432
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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