Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
socs3aSuppressor of cytokine-signaling 3a. (207 aa)    
Predicted Functional Partners:
jak1
Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
   
 0.982
lepr
Leptin receptor.
   
 0.972
stat3
Signal transducer and activator of transcription.
   
 0.971
tyk2
Tyrosine-protein kinase.
   
 0.971
irs1
Insulin receptor substrate 1.
    
 0.951
jak2b
Tyrosine-protein kinase.
   
 0.948
jak2a
Tyrosine-protein kinase.
   
 0.942
socs1a
Suppressor of cytokine-signaling 1a.
   
 
0.938
insra
Tyrosine-protein kinase receptor.
    
 0.932
insrb
Tyrosine-protein kinase receptor.
    
 0.922
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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