STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pi4k2bPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity) (501 aa)    
Predicted Functional Partners:
pikfyve
Phosphatidylinositol phosphate 5-kinase type III isoform a; Phosphoinositide kinase, FYVE finger containing
   
 
 0.949
pik3c3
Phosphatidylinositol 3-kinase, catalytic subunit type 3; Phosphoinositide-3-kinase, class 3; Belongs to the PI3/PI4-kinase family
   
 0.941
pi4kb
Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP)
   
 0.941
m1ap
Meiosis 1 associated protein
      
 0.937
pi4kaa
Phosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family
   
 0.919
pik3c2b
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Phosphoinositide-3-kinase, class 2, beta polypeptide; Belongs to the PI3/PI4-kinase family
   
 0.915
pik3c2a
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Phosphoinositide-3-kinase, class 2, alpha polypeptide; Belongs to the PI3/PI4-kinase family
   
 0.914
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
   
 
 0.907
ptenb
Phosphatase and tensin-like protein B long splice variant; Phosphatase and tensin homolog B
   
 
 0.902
ptena
Phosphatase and tensin homolog A
   
 
 0.902
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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