STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plekhf2Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. (247 aa)    
Predicted Functional Partners:
plekhh2
Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2.
      
 0.898
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
      
 0.865
fam43a
Family with sequence similarity 43 member A.
      
 0.861
snx29
Sorting nexin 29.
    
 
 0.821
Plekhg1
DH domain-containing protein.
      
 0.807
tox4a
TOX high mobility group box family member 4 a.
      
 0.803
nop53
Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.
      
 0.803
lrrc4ca
Leucine-rich repeat-containing 4C, genome duplicate a.
      
 0.745
phf5a
PHD finger protein 5A.
      
 0.740
col6a4a
Collagen, type VI, alpha 4a.
      
 0.740
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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