Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
herpud2Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway. (397 aa)    
Predicted Functional Partners:
rnf165a
Ring finger protein 165a.
      
 0.836
ogfod1
2-oxoglutarate and iron-dependent oxygenase domain-containing 1.
      
 0.612
rnf126
Ring finger protein 126.
      
 0.595
amfra
Autocrine motility factor receptor a.
    
 
 0.582
syvn1
E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm a [...]
    
 
 0.582
amfrb
Autocrine motility factor receptor b.
    
 
 0.582
march4
E3 ubiquitin-protein ligase MARCH4.
      
 0.577
march4l
E3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
      
 0.577
mbtps2
Membrane-bound transcription factor peptidase, site 2.
      
 0.524
dnajb9b
DnaJ heat shock protein family (Hsp40) member B9b.
   
  
 0.515
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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