node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000142481 | brd2a | ENSDARP00000142481 | ENSDARP00000038787 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Bromodomain-containing protein 2a. | 0.749 |
brd2a | ENSDARP00000142481 | ENSDARP00000038787 | ENSDARP00000142481 | Bromodomain-containing protein 2a. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.749 |
brd2a | cdk9 | ENSDARP00000038787 | ENSDARP00000065858 | Bromodomain-containing protein 2a. | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. | 0.719 |
brd2a | crbn | ENSDARP00000038787 | ENSDARP00000062723 | Bromodomain-containing protein 2a. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | 0.742 |
brd2a | hist1h4l | ENSDARP00000038787 | ENSDARP00000077832 | Bromodomain-containing protein 2a. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.749 |
brd2a | psmb8a | ENSDARP00000038787 | ENSDARP00000095608 | Bromodomain-containing protein 2a. | Proteasome subunit beta. | 0.738 |
brd2a | psmb9a | ENSDARP00000038787 | ENSDARP00000001220 | Bromodomain-containing protein 2a. | Proteasome subunit beta. | 0.695 |
brd2a | rgl2 | ENSDARP00000038787 | ENSDARP00000025191 | Bromodomain-containing protein 2a. | Ral guanine nucleotide dissociation stimulator-like 2. | 0.780 |
brd2a | rxrba | ENSDARP00000038787 | ENSDARP00000125725 | Bromodomain-containing protein 2a. | Retinoic acid receptor RXR-beta-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.730 |
brd2a | taf7 | ENSDARP00000038787 | ENSDARP00000133252 | Bromodomain-containing protein 2a. | TAF7 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. | 0.685 |
brd2a | tapbp.1 | ENSDARP00000038787 | ENSDARP00000095615 | Bromodomain-containing protein 2a. | TAP-binding protein (tapasin), tandem duplicate 1. | 0.695 |
cdk9 | brd2a | ENSDARP00000065858 | ENSDARP00000038787 | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. | Bromodomain-containing protein 2a. | 0.719 |
cdk9 | crbn | ENSDARP00000065858 | ENSDARP00000062723 | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | 0.423 |
crbn | brd2a | ENSDARP00000062723 | ENSDARP00000038787 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | Bromodomain-containing protein 2a. | 0.742 |
crbn | cdk9 | ENSDARP00000062723 | ENSDARP00000065858 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. | 0.423 |
hist1h4l | brd2a | ENSDARP00000077832 | ENSDARP00000038787 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Bromodomain-containing protein 2a. | 0.749 |
psmb8a | brd2a | ENSDARP00000095608 | ENSDARP00000038787 | Proteasome subunit beta. | Bromodomain-containing protein 2a. | 0.738 |
psmb8a | psmb9a | ENSDARP00000095608 | ENSDARP00000001220 | Proteasome subunit beta. | Proteasome subunit beta. | 0.994 |
psmb8a | rgl2 | ENSDARP00000095608 | ENSDARP00000025191 | Proteasome subunit beta. | Ral guanine nucleotide dissociation stimulator-like 2. | 0.744 |
psmb8a | rxrba | ENSDARP00000095608 | ENSDARP00000125725 | Proteasome subunit beta. | Retinoic acid receptor RXR-beta-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.833 |