Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tp53inp1Tumor protein p53-inducible nuclear protein 1. (241 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
 0.929
map1lc3c
Microtubule-associated protein 1 light chain 3 gamma.
    
 0.912
zgc:92606
Zgc:92606.
    
 0.911
map1lc3cl
Microtubule-associated protein 1 light chain 3 gamma,-like.
    
 0.911
vmp1
Vacuole membrane protein 1; Belongs to the VMP1 family.
     
 0.891
ENSDARP00000151911
Si:ch211-260e23.9.
     
  0.869
map1lc3a
Microtubule-associated protein 1 light chain 3 alpha.
    
 0.838
map1lc3b
Microtubule-associated protein 1 light chain 3 beta.
    
 0.838
gabarapl2
GABA(A) receptor-associated protein-like 2.
    
 0.801
gabarapa
GABA(A) receptor-associated protein a.
    
 0.801
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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