node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
asb15b | nfkbiab | ENSDARP00000114637 | ENSDARP00000015303 | Ankyrin repeat and SOCS box-containing 15b. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | 0.487 |
asb15b | tp53inp1 | ENSDARP00000114637 | ENSDARP00000038892 | Ankyrin repeat and SOCS box-containing 15b. | Tumor protein p53-inducible nuclear protein 1. | 0.652 |
hipk2 | pin1 | ENSDARP00000084768 | ENSDARP00000134093 | Homeodomain-interacting protein kinase 2. | Peptidyl-prolyl cis-trans isomerase. | 0.952 |
hipk2 | tp53 | ENSDARP00000084768 | ENSDARP00000116736 | Homeodomain-interacting protein kinase 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.971 |
hipk2 | tp53inp1 | ENSDARP00000084768 | ENSDARP00000038892 | Homeodomain-interacting protein kinase 2. | Tumor protein p53-inducible nuclear protein 1. | 0.685 |
nfkbiab | asb15b | ENSDARP00000015303 | ENSDARP00000114637 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Ankyrin repeat and SOCS box-containing 15b. | 0.487 |
nfkbiab | sesn2 | ENSDARP00000015303 | ENSDARP00000093160 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Sestrin 2. | 0.454 |
nfkbiab | tp53 | ENSDARP00000015303 | ENSDARP00000116736 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.550 |
nfkbiab | tp53inp1 | ENSDARP00000015303 | ENSDARP00000038892 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Tumor protein p53-inducible nuclear protein 1. | 0.530 |
nfkbiab | upp1 | ENSDARP00000015303 | ENSDARP00000059904 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.556 |
pin1 | hipk2 | ENSDARP00000134093 | ENSDARP00000084768 | Peptidyl-prolyl cis-trans isomerase. | Homeodomain-interacting protein kinase 2. | 0.952 |
pin1 | tp53 | ENSDARP00000134093 | ENSDARP00000116736 | Peptidyl-prolyl cis-trans isomerase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.835 |
pin1 | tp53inp1 | ENSDARP00000134093 | ENSDARP00000038892 | Peptidyl-prolyl cis-trans isomerase. | Tumor protein p53-inducible nuclear protein 1. | 0.499 |
ppp1caa | prkra | ENSDARP00000002360 | ENSDARP00000036697 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog; Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity). | 0.816 |
ppp1caa | tp53inp1 | ENSDARP00000002360 | ENSDARP00000038892 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Tumor protein p53-inducible nuclear protein 1. | 0.666 |
prkra | ppp1caa | ENSDARP00000036697 | ENSDARP00000002360 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog; Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity). | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.816 |
prkra | tp53inp1 | ENSDARP00000036697 | ENSDARP00000038892 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog; Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity). | Tumor protein p53-inducible nuclear protein 1. | 0.627 |
rnf6 | tp53inp1 | ENSDARP00000099863 | ENSDARP00000038892 | Ring finger protein (C3H2C3 type) 6. | Tumor protein p53-inducible nuclear protein 1. | 0.499 |
sesn2 | nfkbiab | ENSDARP00000093160 | ENSDARP00000015303 | Sestrin 2. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | 0.454 |
sesn2 | tp53 | ENSDARP00000093160 | ENSDARP00000116736 | Sestrin 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.588 |