| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000148213 | PLCB1 | ENSDARP00000148213 | ENSDARP00000153275 | PH_14 domain-containing protein. | Phosphoinositide phospholipase C. | 0.878 |
| ENSDARP00000148213 | PLCB4 | ENSDARP00000148213 | ENSDARP00000133895 | PH_14 domain-containing protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.893 |
| ENSDARP00000148213 | itpr1a | ENSDARP00000148213 | ENSDARP00000151640 | PH_14 domain-containing protein. | Inositol 1,4,5-trisphosphate receptor, type 1a. | 0.892 |
| ENSDARP00000148213 | itpr2 | ENSDARP00000148213 | ENSDARP00000128737 | PH_14 domain-containing protein. | Inositol 1,4,5-trisphosphate receptor, type 2. | 0.889 |
| ENSDARP00000148213 | itpr3 | ENSDARP00000148213 | ENSDARP00000133340 | PH_14 domain-containing protein. | Inositol 1,4,5-trisphosphate receptor, type 3. | 0.937 |
| ENSDARP00000148213 | plce1 | ENSDARP00000148213 | ENSDARP00000112202 | PH_14 domain-containing protein. | Phospholipase C, epsilon 1. | 0.880 |
| ENSDARP00000148213 | plcg1 | ENSDARP00000148213 | ENSDARP00000120537 | PH_14 domain-containing protein. | Phosphoinositide phospholipase C. | 0.892 |
| ENSDARP00000148213 | plcg2 | ENSDARP00000148213 | ENSDARP00000075155 | PH_14 domain-containing protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.845 |
| ENSDARP00000148213 | prkcbb | ENSDARP00000148213 | ENSDARP00000038918 | PH_14 domain-containing protein. | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] | 0.907 |
| PLCB1 | ENSDARP00000148213 | ENSDARP00000153275 | ENSDARP00000148213 | Phosphoinositide phospholipase C. | PH_14 domain-containing protein. | 0.878 |
| PLCB1 | PLCB4 | ENSDARP00000153275 | ENSDARP00000133895 | Phosphoinositide phospholipase C. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.912 |
| PLCB1 | itpr1a | ENSDARP00000153275 | ENSDARP00000151640 | Phosphoinositide phospholipase C. | Inositol 1,4,5-trisphosphate receptor, type 1a. | 0.892 |
| PLCB1 | itpr2 | ENSDARP00000153275 | ENSDARP00000128737 | Phosphoinositide phospholipase C. | Inositol 1,4,5-trisphosphate receptor, type 2. | 0.889 |
| PLCB1 | itpr3 | ENSDARP00000153275 | ENSDARP00000133340 | Phosphoinositide phospholipase C. | Inositol 1,4,5-trisphosphate receptor, type 3. | 0.937 |
| PLCB1 | plce1 | ENSDARP00000153275 | ENSDARP00000112202 | Phosphoinositide phospholipase C. | Phospholipase C, epsilon 1. | 0.880 |
| PLCB1 | plcg1 | ENSDARP00000153275 | ENSDARP00000120537 | Phosphoinositide phospholipase C. | Phosphoinositide phospholipase C. | 0.892 |
| PLCB1 | plcg2 | ENSDARP00000153275 | ENSDARP00000075155 | Phosphoinositide phospholipase C. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.845 |
| PLCB1 | prkcbb | ENSDARP00000153275 | ENSDARP00000038918 | Phosphoinositide phospholipase C. | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] | 0.907 |
| PLCB4 | ENSDARP00000148213 | ENSDARP00000133895 | ENSDARP00000148213 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | PH_14 domain-containing protein. | 0.893 |
| PLCB4 | PLCB1 | ENSDARP00000133895 | ENSDARP00000153275 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | Phosphoinositide phospholipase C. | 0.912 |
