Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ptp4a3aProtein tyrosine phosphatase type IVA, member 3. (173 aa)    
Predicted Functional Partners:
C11orf96
AlkB homolog 3, alpha-ketoglutarate-dependent dioxygenase.
      
 0.828
myct1b
Myc target 1b.
      
 0.711
ENSDARP00000133413
Si:dkey-220o5.5.
      
 0.666
plekhj1
Pleckstrin homology domain-containing family J member 1.
      
 0.661
glg1a
Golgi glycoprotein 1a.
      
 0.661
gpatch1
G patch domain-containing 1.
      
 0.594
znf526
Zinc finger protein 526.
      
 0.594
phlda3
Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).
   
  
 0.582
znf574
Zinc finger protein 574.
      
 0.562
pim3
Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
      
 0.506
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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