Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
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[Homology]
Score
tsg101aTumor susceptibility 101a. (390 aa)    
Predicted Functional Partners:
vps28
Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
   
 0.997
vps37a
Vacuolar protein sorting 37A.
   
 0.993
cd63
Tetraspanin.
    
 
 0.992
hgs
Hepatocyte growth factor-regulated tyrosine kinase substrate.
   
 0.990
vps37b
VPS37B subunit of ESCRT-I.
   
 0.987
vps37c
VPS37C subunit of ESCRT-I.
   
 0.986
mvb12a
Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
    
 0.984
tsg101b
Tumor susceptibility 101b.
  
  
 
0.982
X1WEV5_DANRE
Si:ch211-284f22.3.
   
 0.978
zgc:114173
Zgc:114173.
   
 0.976
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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