| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bmp7a | pax2a | ENSDARP00000017352 | ENSDARP00000071466 | Bone morphogenetic protein 7a. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.668 |
| bmp7a | shha | ENSDARP00000017352 | ENSDARP00000125090 | Bone morphogenetic protein 7a. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.771 |
| bmp7a | six3a | ENSDARP00000017352 | ENSDARP00000075254 | Bone morphogenetic protein 7a. | Sine oculis homeobox homolog 3a. | 0.423 |
| bmp7a | six3b | ENSDARP00000017352 | ENSDARP00000071625 | Bone morphogenetic protein 7a. | Sine oculis homeobox homolog 3b. | 0.493 |
| bmp7a | vax1 | ENSDARP00000017352 | ENSDARP00000039283 | Bone morphogenetic protein 7a. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.561 |
| foxe1 | irf6 | ENSDARP00000127024 | ENSDARP00000139404 | Forkhead box E1. | Interferon regulatory factor 6. | 0.807 |
| foxe1 | pax2a | ENSDARP00000127024 | ENSDARP00000071466 | Forkhead box E1. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.401 |
| foxe1 | vax1 | ENSDARP00000127024 | ENSDARP00000039283 | Forkhead box E1. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.582 |
| irf6 | foxe1 | ENSDARP00000139404 | ENSDARP00000127024 | Interferon regulatory factor 6. | Forkhead box E1. | 0.807 |
| irf6 | shha | ENSDARP00000139404 | ENSDARP00000125090 | Interferon regulatory factor 6. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.443 |
| irf6 | vax1 | ENSDARP00000139404 | ENSDARP00000039283 | Interferon regulatory factor 6. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.682 |
| ntn1b | shha | ENSDARP00000038885 | ENSDARP00000125090 | Netrin 1b. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.647 |
| ntn1b | vax1 | ENSDARP00000038885 | ENSDARP00000039283 | Netrin 1b. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.556 |
| pax2a | bmp7a | ENSDARP00000071466 | ENSDARP00000017352 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Bone morphogenetic protein 7a. | 0.668 |
| pax2a | foxe1 | ENSDARP00000071466 | ENSDARP00000127024 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Forkhead box E1. | 0.401 |
| pax2a | shha | ENSDARP00000071466 | ENSDARP00000125090 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.858 |
| pax2a | six3a | ENSDARP00000071466 | ENSDARP00000075254 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sine oculis homeobox homolog 3a. | 0.783 |
| pax2a | six3b | ENSDARP00000071466 | ENSDARP00000071625 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sine oculis homeobox homolog 3b. | 0.777 |
| pax2a | smoc1 | ENSDARP00000071466 | ENSDARP00000112037 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | SPARC-related modular calcium-binding 1. | 0.410 |
| pax2a | vax1 | ENSDARP00000071466 | ENSDARP00000039283 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.868 |