Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
usp4Ubiquitin-specific peptidase 4 (proto-oncogene); Belongs to the peptidase C19 family. (1009 aa)    
Predicted Functional Partners:
sart3
Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity).
    
 
 0.935
traf6
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.
    
 0.871
ubc
Ubiquitin C.
    
 0.815
usp14
Ubiquitin carboxyl-terminal hydrolase.
    
 
0.800
ubb
Ubiquitin B.
    
 0.785
prpf3
PRP3 pre-mRNA-processing factor 3 homolog (yeast).
   
 
 0.770
tomm70a
Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae).
     
  0.740
smurf2
E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
   
 
 0.734
cylda
Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.
      
 0.732
usp25
Ubiquitin-specific peptidase 25; Belongs to the peptidase C19 family.
   
 
 0.702
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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