STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtn4ip1Reticulon-4-interacting protein 1 homolog, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) maturation, neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (387 aa)    
Predicted Functional Partners:
tmem126a
Transmembrane protein 126A.
   
  
 0.900
cbr1l
Carbonyl reductase 1-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 0.851
rps27.2
40S ribosomal protein S27.
   
 
 0.820
atp5mc3a
ATP synthase membrane subunit c locus 3a; Belongs to the ATPase C chain family.
   
  
 0.767
vwa8
Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro.
    
 
 0.750
tspan7b
Tetraspanin.
      
 0.740
kansl3
KAT8 regulatory NSL complex subunit 3; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
      
 0.688
ascc3
Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for alkbh3, enabling alkbh3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions.
      
 0.687
sdad1
Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.
   
  
 0.677
nop14
NOP14 nucleolar protein homolog (yeast).
   
  
 0.673
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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