node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cnpy1 | cnpy3 | ENSDARP00000009432 | ENSDARP00000040115 | Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | 0.883 |
cnpy1 | hsp90b1 | ENSDARP00000009432 | ENSDARP00000013441 | Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. | Heat shock protein 90, beta (Grp94), member 1. | 0.523 |
cnpy1 | lrrc40 | ENSDARP00000009432 | ENSDARP00000016699 | Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. | Leucine-rich repeat-containing protein 40. | 0.595 |
cnpy2 | cnpy3 | ENSDARP00000149703 | ENSDARP00000040115 | Canopy FGF-signaling regulator 2. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | 0.880 |
cnpy2 | hsp90b1 | ENSDARP00000149703 | ENSDARP00000013441 | Canopy FGF-signaling regulator 2. | Heat shock protein 90, beta (Grp94), member 1. | 0.601 |
cnpy3 | cnpy1 | ENSDARP00000040115 | ENSDARP00000009432 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. | 0.883 |
cnpy3 | cnpy2 | ENSDARP00000040115 | ENSDARP00000149703 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Canopy FGF-signaling regulator 2. | 0.880 |
cnpy3 | fsd1l | ENSDARP00000040115 | ENSDARP00000120509 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Fibronectin type III and SPRY domain-containing 1-like. | 0.744 |
cnpy3 | hsp90b1 | ENSDARP00000040115 | ENSDARP00000013441 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Heat shock protein 90, beta (Grp94), member 1. | 0.733 |
cnpy3 | lrig2 | ENSDARP00000040115 | ENSDARP00000120738 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Leucine-rich repeats and immunoglobulin-like domains 2. | 0.744 |
cnpy3 | lrig3 | ENSDARP00000040115 | ENSDARP00000099511 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Leucine-rich repeats and immunoglobulin-like domains 3. | 0.754 |
cnpy3 | lrrc40 | ENSDARP00000040115 | ENSDARP00000016699 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Leucine-rich repeat-containing protein 40. | 0.832 |
cnpy3 | pdrg1 | ENSDARP00000040115 | ENSDARP00000119567 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | P53 and DNA-damage-regulated 1. | 0.629 |
cnpy3 | rab4a | ENSDARP00000040115 | ENSDARP00000012097 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Ras-related protein Rab-4A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.584 |
cnpy3 | zbtb16a | ENSDARP00000040115 | ENSDARP00000153802 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | Zinc finger and BTB domain-containing protein 16-A; Probable transcription factor. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.545 |
fsd1l | cnpy3 | ENSDARP00000120509 | ENSDARP00000040115 | Fibronectin type III and SPRY domain-containing 1-like. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | 0.744 |
fsd1l | pdrg1 | ENSDARP00000120509 | ENSDARP00000119567 | Fibronectin type III and SPRY domain-containing 1-like. | P53 and DNA-damage-regulated 1. | 0.833 |
hsp90b1 | cnpy1 | ENSDARP00000013441 | ENSDARP00000009432 | Heat shock protein 90, beta (Grp94), member 1. | Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development. | 0.523 |
hsp90b1 | cnpy2 | ENSDARP00000013441 | ENSDARP00000149703 | Heat shock protein 90, beta (Grp94), member 1. | Canopy FGF-signaling regulator 2. | 0.601 |
hsp90b1 | cnpy3 | ENSDARP00000013441 | ENSDARP00000040115 | Heat shock protein 90, beta (Grp94), member 1. | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). | 0.733 |