Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cnpy3Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). (276 aa)    
Predicted Functional Partners:
lrrc40
Leucine-rich repeat-containing protein 40.
    
 
 0.980
cnpy2
Canopy FGF-signaling regulator 2.
      
 0.916
cnpy1
Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development.
      
 0.887
gtf3c4
General transcription factor IIIC, polypeptide 4.
      
 0.720
fsd1l
Fibronectin type III and SPRY domain-containing 1-like.
      
 0.719
hsp90b1
Heat shock protein 90, beta (Grp94), member 1.
   
 
 0.702
trpa1b
Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.664
scrib
Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation.
    
 
 0.640
trpm5
Transient receptor potential cation channel, subfamily M, member 5.
      
 0.634
trpm7
Transient receptor potential cation channel, subfamily M, member 7.
      
 0.630
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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