STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cnpy3Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity). (276 aa)    
Predicted Functional Partners:
cnpy1
Protein canopy-1; Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer. Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development.
      
 0.883
cnpy2
Canopy FGF-signaling regulator 2.
      
 0.880
lrrc40
Leucine-rich repeat-containing protein 40.
    
 
 0.832
lrig3
Leucine-rich repeats and immunoglobulin-like domains 3.
    
 
 0.754
fsd1l
Fibronectin type III and SPRY domain-containing 1-like.
      
 0.744
lrig2
Leucine-rich repeats and immunoglobulin-like domains 2.
    
 
 0.744
hsp90b1
Heat shock protein 90, beta (Grp94), member 1.
   
 
 0.733
pdrg1
P53 and DNA-damage-regulated 1.
      
 0.629
rab4a
Ras-related protein Rab-4A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
   
  
 0.584
zbtb16a
Zinc finger and BTB domain-containing protein 16-A; Probable transcription factor. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis. Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.545
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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