Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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tbc1d7TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). (294 aa)    
Predicted Functional Partners:
tsc1a
TSC complex subunit 1a.
   
 0.999
tsc1b
TSC complex subunit 1b.
    
 0.999
tsc2
TSC complex subunit 2.
    
 0.998
rhebl1
Ras homolog, mTORC1-binding-like 1.
     
 0.993
ENSDARP00000153406
DUF3384 domain-containing protein.
    
 0.992
akt3b
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.965
akt3a
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.960
rps6ka2
Ribosomal protein S6 kinase.
     
 0.956
rps6kal
Ribosomal protein S6 kinase alpha-6; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
     
 0.956
ddit4
DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...]
     
 0.953
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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