Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000153406 | ddit4 | ENSDARP00000153406 | ENSDARP00000127401 | DUF3384 domain-containing protein. | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | 0.479 |
| ENSDARP00000153406 | rheb | ENSDARP00000153406 | ENSDARP00000107964 | DUF3384 domain-containing protein. | Ras homolog, mTORC1-binding. | 0.666 |
| ENSDARP00000153406 | rhebl1 | ENSDARP00000153406 | ENSDARP00000057222 | DUF3384 domain-containing protein. | Ras homolog, mTORC1-binding-like 1. | 0.666 |
| ENSDARP00000153406 | tbc1d7 | ENSDARP00000153406 | ENSDARP00000040264 | DUF3384 domain-containing protein. | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). | 0.911 |
| ENSDARP00000153406 | tsc1a | ENSDARP00000153406 | ENSDARP00000035073 | DUF3384 domain-containing protein. | TSC complex subunit 1a. | 0.926 |
| ENSDARP00000153406 | tsc1b | ENSDARP00000153406 | ENSDARP00000119507 | DUF3384 domain-containing protein. | TSC complex subunit 1b. | 0.926 |
| ENSDARP00000153406 | tsc2 | ENSDARP00000153406 | ENSDARP00000131915 | DUF3384 domain-containing protein. | TSC complex subunit 2. | 0.960 |
| ddit4 | ENSDARP00000153406 | ENSDARP00000127401 | ENSDARP00000153406 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | DUF3384 domain-containing protein. | 0.479 |
| ddit4 | tbc1d7 | ENSDARP00000127401 | ENSDARP00000040264 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). | 0.930 |
| ddit4 | tsc1a | ENSDARP00000127401 | ENSDARP00000035073 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | TSC complex subunit 1a. | 0.926 |
| ddit4 | tsc1b | ENSDARP00000127401 | ENSDARP00000119507 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | TSC complex subunit 1b. | 0.926 |
| ddit4 | tsc2 | ENSDARP00000127401 | ENSDARP00000131915 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] | TSC complex subunit 2. | 0.960 |
| gsk3bb | tbc1d7 | ENSDARP00000068806 | ENSDARP00000040264 | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). | 0.908 |
| gsk3bb | tsc1a | ENSDARP00000068806 | ENSDARP00000035073 | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. | TSC complex subunit 1a. | 0.930 |
| gsk3bb | tsc1b | ENSDARP00000068806 | ENSDARP00000119507 | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. | TSC complex subunit 1b. | 0.924 |
| gsk3bb | tsc2 | ENSDARP00000068806 | ENSDARP00000131915 | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. | TSC complex subunit 2. | 0.945 |
| ikbkb | tbc1d7 | ENSDARP00000117685 | ENSDARP00000040264 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). | 0.903 |
| ikbkb | tsc1a | ENSDARP00000117685 | ENSDARP00000035073 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TSC complex subunit 1a. | 0.936 |
| ikbkb | tsc1b | ENSDARP00000117685 | ENSDARP00000119507 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TSC complex subunit 1b. | 0.936 |
| ikbkb | tsc2 | ENSDARP00000117685 | ENSDARP00000131915 | Inhibitor of nuclear factor kappa B kinase subunit beta. | TSC complex subunit 2. | 0.933 |
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