| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dazl | ddx4 | ENSDARP00000113712 | ENSDARP00000111634 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | 0.968 |
| dazl | dnd1 | ENSDARP00000113712 | ENSDARP00000035017 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Dead end protein 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development. | 0.981 |
| dazl | gra | ENSDARP00000113712 | ENSDARP00000098356 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Granulito. | 0.577 |
| dazl | nanos1 | ENSDARP00000113712 | ENSDARP00000149427 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Nanos homolog 1; Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES- driven, polyadenylated RNAs or nonpolyadenylated RNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival. | 0.874 |
| dazl | nanos3 | ENSDARP00000113712 | ENSDARP00000089386 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Nanos homolog 3; Belongs to the nanos family. | 0.948 |
| dazl | piwil1 | ENSDARP00000113712 | ENSDARP00000121147 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Piwi-like protein 1; Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other [...] | 0.934 |
| dazl | piwil2 | ENSDARP00000113712 | ENSDARP00000114406 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in germ cell differentiation and meiosis, independently of the function in transposable elements repression. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosyn [...] | 0.823 |
| dazl | tdrd12 | ENSDARP00000113712 | ENSDARP00000156644 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Tudor domain-containing 12. | 0.463 |
| dazl | tdrd7a | ENSDARP00000113712 | ENSDARP00000040306 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | Tudor domain-containing protein 7A; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs). | 0.828 |
| dazl | tdrd9 | ENSDARP00000113712 | ENSDARP00000011360 | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a n [...] | 0.720 |
| ddx4 | dazl | ENSDARP00000111634 | ENSDARP00000113712 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Deleted in azoospermia-like; RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity). | 0.968 |
| ddx4 | dnd1 | ENSDARP00000111634 | ENSDARP00000035017 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Dead end protein 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development. | 0.909 |
| ddx4 | gra | ENSDARP00000111634 | ENSDARP00000098356 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Granulito. | 0.580 |
| ddx4 | nanos1 | ENSDARP00000111634 | ENSDARP00000149427 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Nanos homolog 1; Acts as a translational repressor. Can mediate repression affecting different steps in the translation process: cap-driven, IRES- driven, polyadenylated RNAs or nonpolyadenylated RNAs (By similarity). Essential for the development of primordial germ cells (PGCs) by ensuring their proper migration and survival. | 0.575 |
| ddx4 | nanos3 | ENSDARP00000111634 | ENSDARP00000089386 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Nanos homolog 3; Belongs to the nanos family. | 0.834 |
| ddx4 | piwil1 | ENSDARP00000111634 | ENSDARP00000121147 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Piwi-like protein 1; Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other [...] | 0.931 |
| ddx4 | piwil2 | ENSDARP00000111634 | ENSDARP00000114406 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in germ cell differentiation and meiosis, independently of the function in transposable elements repression. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosyn [...] | 0.842 |
| ddx4 | tdrd12 | ENSDARP00000111634 | ENSDARP00000156644 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Tudor domain-containing 12. | 0.672 |
| ddx4 | tdrd7a | ENSDARP00000111634 | ENSDARP00000040306 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | Tudor domain-containing protein 7A; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs). | 0.769 |
| ddx4 | tdrd9 | ENSDARP00000111634 | ENSDARP00000011360 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. | ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a n [...] | 0.789 |
